Get this medication by mouth with or without meals as directed by your health care provider, commonly every 4 to 6 hours as desired. This medication may be taken with food if abdomen upset happens. Drink lots of fluids when you use this medication unless usually directed by your physician.
Hazard Summary As a result of potential for really serious adverse reactions, such as surplus sedation, respiratory despair, and Loss of life in a very breastfed infant, advise sufferers that breastfeeding is not advisable throughout treatment method with Promethazine with Codeine Oral Alternative [see Warnings and Precautions ( five.
The opioid antagonists, naloxone and nalmefene, are distinct antidotes for respiratory melancholy resulting from opioid overdose. For clinically major respiratory or circulatory melancholy secondary to codeine overdose, administer an opioid antagonist. An antagonist really should not be administered within the absence of clinically sizeable respiratory depression. Since the length of opioid reversal is predicted to become below the duration of motion of codeine in Promethazine with Codeine Oral Option, very carefully monitor the patient until finally spontaneous respiration is reliably reestablished.
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While it can help A lot of people, this medication has a hazard for abuse and could in some cases cause dependancy. This danger can be larger When you have a material use disorder (which include overuse of or dependancy to drugs/alcohol).
Inform your doctor In case you are pregnant or think you might be Expecting. During pregnancy, this product or service will not be advised. It could harm an unborn baby. Speak to your health practitioner regarding the hazards and benefits of this medication. See also Warning section.
No proof of tumorigenicity was noticed in male and woman mice at codeine dietary doses around 400 mg/kg/day (roughly such as 45 times the MRHD on a mg/m2 basis).
For the reason that these reactions could possibly be reported voluntarily from the populace of uncertain size, It isn't usually possible to reliably estimate their frequency or build a causal romance to drug exposure.
Diligently measure the dose utilizing a special measuring product/spoon. Do not utilize a residence spoon simply click here because you may not get the correct dose.
Codeine could cause miosis, even in overall darkness. Pinpoint pupils are an indication of opioid overdose but are certainly not pathognomonic (eg., pontine lesions of hemorrhagic or ischemic origin may produce identical conclusions). Marked mydriasis rather then miosis may be seen with hypoxia in overdose cases [see
Steer clear of driving or working machinery until finally you know how Promethazine VC with Codeine will impact you. Dizziness or significant drowsiness might cause falls or other accidents.
To lower your threat, your medical professional should have you go ahead and take smallest dose that works, and consider it with the shortest possible time. See also How to Use segment To learn more about habit.
Existence-threatening respiratory depression and Demise have transpired in kids who been given codeine. Codeine is issue to variability in metabolism primarily based upon CYP2D6 genotype (described underneath), which may lead to an increased exposure on the Energetic metabolite morphine. Centered upon post-advertising reviews, youngsters more youthful than twelve yrs previous look like far more prone to the respiratory depressant consequences of codeine, specifically if you will find risk things for respiratory melancholy.
Before getting this medication, tell your health care provider or pharmacist If you're allergic to any of its components; or to opioid pain relievers (for instance morphine); or When you have any other allergy symptoms.